Wouldn’t it make sense to add the whole sentence?

Встречается и обособленно
https://tommilsom.bandcamp.com/track/live-in-spite
Live In Spite - название
Однако,
I don't want to live in this way any more
Everything is fine
I don't want to live in spite OF it all
When there is nothing on my mind

I don't want to live in spite of it all

Еще песенка - Live Your Life In Spite
Whatever people say you "should" do, go ahead and do the opposite, because you know what's best for you.
Но, опять же, Live your life in spite OF what people say, and I bet you'll smile a little bit more.

Живи вопреки (?)

I guess so. It doesn’t sound very natural to me in English. 

Element eighty - spite

В контексте песни