His work was mentally exhausting, and eventually it took its toll on his health. — Его работа была изматывающей и в конечном счёте дурно повлияла на его здоровье.
The war has taken their toll, and the population of the region is greatly reduced. — Война сыграла свою отрицательную роль, и население области теперь сильно сократилось.